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And of everything that I've done since I've been on social media, which hasn't been that long, by the way, I haven't had such an overwhelmingly positive response as I have from The Normal Heart directly to me. If this is it, if I have a piano dropped on me tomorrow, then I would go down thinking, "You know what, I did okay as far as my career goes, because that's a gift.
That's rare." In 2015, Ruffalo received his second Academy Award nomination for his portrayal of wrestler Dave Schultz in the biographical drama Foxcatcher.
In 2010, he starred in the psychological thriller Shutter Island and the comedy-drama The Kids Are All Right.
For the latter, he received nominations for the SAG Award, BAFTA Award, and an Academy Award for Best Supporting Actor.
In 2010, he starred in Lisa Cholodenko's The Kids Are All Right, with Annette Bening and Julianne Moore.
Ruffalo stated in an interview that he approached Cholodenko after watching High Art and said he would love to work with her.
He has explained his stance by saying: "I don't want to turn back the hands of time to when women shuttled across state lines in the thick of night to resolve an unwanted pregnancy, in a cheap hotel room." although he has received backlash from the transgender community for supporting the casting of a cisgender man, Matt Bomer, to play a transgender woman in the film Anything, of which Ruffalo was an executive producer.
2008 also saw Ruffalo in Brian Goodman's What Doesn't Kill You with Ethan Hawke and Amanda Peet, which was shown at the Toronto International Film Festival.
He was part of the original cast of This Is Our Youth (1996), for which he was nominated for an Independent Spirit Award.
Following were his roles in 13 Going on 30 (2004), Eternal Sunshine of the Spotless Mind (2004), Zodiac (2007), and What Doesn't Kill You (2008).
Later in the year, he starred as a bipolar father-of-two in the independent comedy film Infinitely Polar Bear, for which he earned a Golden Globe Award nomination, and he also appeared as journalist Michael Rezendes in the drama film Spotlight, for which he earned his third Academy Award nomination and a BAFTA Award nomination.
He directed a number of plays during his time at the Orpheus Theatre Company, and made his feature film directorial debut with Sympathy for Delicious, which premiered at the Sundance Film Festival and won the Special Jury Prize.