Elucidating protein structure

Rated 3.99/5 based on 745 customer reviews

Biochemists and biologists often begin with a specific protein and seek to identify the endogenous metabolites that bind to it.These interests have led to the development of methodology that relies heavily on synthetic and analytical chemistry to identify protein-small molecule and protein-metabolite interactions.In addition to elucidating protein functions, structural genomics can be used to identify novel protein folds and potential targets for drug discovery.Structural genomics involves taking a large number of approaches to structure determination, including experimental methods using genomic sequences or modeling-based approaches based on sequence or structural homology to a protein of known structure or based on chemical and physical principles for a protein with no homology to any known structure.This requires new ways of communicating this structural information to the broader research community.The Bioinformatics core of the Joint center for structural genomics (JCSG) has recently developed a wiki-based approach namely Open protein structure annotation network (TOPSAN) for annotating protein structures emerging from high-throughput structural genomics centers.

These proteins are then purified and crystallized, and then subjected to one of two types of structure determination: X-ray crystallography and nuclear magnetic resonance (NMR).determining protein function from its 3D structure.Structural genomics emphasizes high throughput determination of protein structures.Structural genomics takes advantage of completed genome sequences in several ways in order to determine protein structures.The gene sequence of the target protein can also be compared to a known sequence and structural information can then be inferred from the known protein’s structure.

Leave a Reply